Mocravimod hydrochloride( KRP-203 )

Catalog No. M26300 CAS No. 509088-69-1

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Product Name

Mocravimod hydrochloride
Note

Research use only, not for human use.
Brief Description

Mocravimod hydrochloride is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).
Description

Mocravimod hydrochloride is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1). (In Vivo):In mHC-disparate rat heart allografts, Mocravimod hydrochloride(orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection. Mocravimod hydrochloride ameliorates atherosclerosis in LDL-R(-/-) Mice.
In Vitro

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In Vivo

Animal Model:Inbred male DA (MHC haplotype: RT1a) rats Dosage:0.1 and 1 mg/kg Administration:Orally; daily; for 100 days.Result:Prolonged graft survival and attenuated chronic rejection in mHC-disparate rat heart allografts.
Synonyms

KRP-203
Pathway

Others
Target

Other Targets
Recptor

gluconeogenesis
Research Area

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Indication

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1.Murray AF, et, al. Phenylpropanoid Glycerol Glucosides Attenuate Glucose Production in Hepatocytes. ACS Omega. 2019 Jun 19;4(6):10670-10676.

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